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Most of us are aware of the many health problems stress and depression can cause and that it impacts the immune system as well. A stress hormone called cortisol can completely mess with the functioning and effectiveness of the immune system by changing the way white blood cells react to infections and other harmful pathogens. Other coping mechanisms used to reduce stress are drinking and smoking which can again harm your immunity in a big way. In other words, stress can drastically reduce the way the immune system behaves, making individuals prone to more health issues.